The American Bottom is a road ultra endurance event held near Columbia, Illinois, close to St. Louis, Missouri. The course follows the Mississippi River through historic sites such as Piggott's Fort, Fort de Chartres, and Prairie du Rocher. Participants will experience a mix of levees and backroads while taking in views of the Illinois bluffs. The event offers a flat and fast course, featuring multiple aid stations and generous cutoff times. It is suitable for both beginners seeking their first ultra experience and experienced runners aiming to achieve a personal record.